Home  Project catalog  Genome Diversity Project

More information

Project name Genome Diversity Project
Area drug discovery
Purpose

This project is being undertaken to collect genetic polymorphism information relating to model diseases (such as autoimmune diseases, diabetes, eating disorders, cancer, etc.). It also aims to develop a technique to associate disease-related or drug sensitive genes with the differences in their expression, for example, why some people have a particular medical condition such as an allergy and others do not. The results will be used to develop analysis technology and create a useful database. (Ref. http://www.nedo.go.jp/kankobutsu/pamphlets/kouhou/outline2005.pdf (P. 15))1
Introduction

It also aims to develop a technique to associate disease-related or drug sensitive genes with the differences in their expression, for example, why some people have a particular medical condition such as an allergy and others do not. The results will be used to develop analysis technology and create a useful database.

Keyword genome-wide association study | microsatellite | SNP | disease | polymorphism | genetic statistics
Started fiscal year 2001-2005
Project head Takashi Gojobori
Institute of the head Center for Information Biology and DNA Data Bank of Japan (CIB-DDBJ), National Institute of Genetics (NIG)|Biomedicinal Information Research Center (BIRC), National Institute of Advanced Industrial Science and Technology (AIST)
Budget (million yen) 753.7
Representative Institute of the commission Japan Biological Informatics Consortium (JBiC)
Companies Japan Biological Informatics Consortium | Chugai Pharmaceutical CO., LTD. | Nisshinbo Industries, Inc. | TOYOBO GENE ANALYSIS CO.,LTD. | Applied Materials Japan, Inc. | Astellas Pharma Inc. | Fujitsu Limited | Mitsubishi Research Institute, Inc. | NEC Corporation | Research Institute, Mitsui Knowledge Industry CO., LTD. | Hitachi Software Engineering CO., LTD. | NTT DATA Corporation | Japanese Foundation For Cancer Research | Tokai University | The University of Tokushima | The University of Tokyo | Juntendo University | Tokyo Women's Medical University | Waseda University | National Institute of Genetics | Aich Cancer Center | Hiroshima University | National Institute of Advanced Industrial Science and Technology | International Medical Center of Japan | National Center of Neurology and Psychiatry, Japan | Nagoya University
Published papers (PubMed IDs) Under investigation
Patent (Japan, overseas) JP2004325419(A) | JP2005038279(A) | JP2005085063(A) | JP2005092719(A) | JP2005129024(A) | JP2005278479(A) | JP2005312364(A) | JP2006024063(A) | JP2006048429(A) | JP2006065529(A) | JP2006079334(A) | JP2006277611(A) | JP2007074916(A) | JP2007097486(A) | JP2007233485(A) | JP2008021028(A) | JP2004192018(A) | JP2004173505(A) | JP2004272350(A)
Archives
The report on "Genome Diversity Project" 2003-2005. Japanese.

Product (Database, Tool)

GRisk

Summary
Data type

HapRisk

Under investigation
[ Show detail ]
Summary
Data type

Human-Gene diversity Of Life-style related Diseases (H-GOLD)

Summary Genetic polymorphism information relating to model diseases. This site provides two databases and seven (downloadable) analysis tools.
Data type , microsatellites, SNP

Integrated Cancer Genome Database

Summary In order to identify genes responsible for drug sensitivities and side effects of anti-cancer drugs, the project genotyped about 3,000 SNPs in candidate genes for breast cancer patients by the Invader method. The database stores genotype frequencies of these SNPs and their relation with drug sensitivities and side effects. The candidate genes include 512 genes related to pharmacokinetics, DNA repair, apotosis, cell cycle control, angiogenesis, and inflammation. The database provides genotype frequencies of these SNPs and it is downloadable.
Data type

SNP-system

Summary We developed SNP-system which is unified in common interface and released it on the web.
Data type DNA-sequence

Relating project

Nothing