To finish safety check of existing chemical substance (approximately 28,000 categories) widely used in Japan now, we need a flood of times and funds. Therefore, we need to review the "safety check project of existing chemical substance" excuted in the past. Untill now, acquired data about degradability and accumulation property remain approximately 1,200. Evaluation data about safety is not developed enough.

To speed-up safety check of chemical substance which should be tackled as quickly as possible (production・import amount 100 ton / year : about 4,000 substance ), this project develop chemical substance property prediction database with existing data and newly obtained data (about 300 substance) and with Quantitative Structure-Activity Relationship (QSAR) .

( cited NEDO http://www.nedo.go.jp/activities/portal/gaiyou/p00002/p00002.html )

Summary of accomplishment:

・Development of a chemical safety prediction system based on the quantitative

structure-activity relationships (SAR) method.

・Implementation of the biodegradation and bioaccumulation study of the existing

chemicals for the check of their safety