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| Project name | Basic technology development of protein structural analysis for acceleration of drug discovery research |
|---|---|
| Area | Biotechnology・medical technology |
| Purpose | To accelerate genomic drug discovery, this project developed basic technology for structural analysis of membrane proteins and their complex in cell surface layer, intractive analysis, efficient search of chemical compound candidates for drug discovery by utilizing computational science and lead compounds with high practical utility. |
| Introduction | R&D contents: 1. Structural analysis technology of membrane proteins and their complex using electron beam etc. 2. Interactive analyses technology for membrane proteins, their complex and ligand molecules using nuclear magnetic resonance method etc. 3. Simulation technology for high accuracy in silico screening etc. |
| Keyword | Membrane protein | Structural analysis | Crystallization | Interactive analyse for ligand molecule | In silico screening |
| Started fiscal year | 2008-2011 |
| Project head | Yoshinori Fujiyoshi |
| Institute of the head | Graduate School of Science / Faculty of Science, Kyoto University |
| Budget (million yen) | 980 (H19) | 838 (H20) |
| Representative Institute of the commission | New Energy and Industrial Technology Development Organization (NEDO) |
| Companies | Japan Biological Informatics Consortium (JBiC) | AJINOMOTO CO., INC. | Astellas Pharma Inc. | Eisai Co., Ltd. | Kyowa Hakko Kirin Co., Ltd. | SHIONOGI & CO., LTD. | Information and Mathematical Science Laboratory Inc. | DAIICHI SANKYO CO., LTD. | TORAY INDUSTRIES, INC. | TORAY RESEARCH CENTER, INC. | JEOL Ltd. | Fujitsu Ltd. | Hitachi Software Engineering Co., Ltd. | MITSUI CHEMICALS AGRO, INC | Mitsubishi Chemical Corporation | ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (AIST) | ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (AIST) |Biomedicinal Information Research Center (BIRC) | ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (AIST) Neuroscience Research Institute | GRADUATE SCHOOL OF SCIENCE AND FACULTY OF SCIENCE,KYOTO UNIVERSITY | Faculty/Graduate School of Agriculture, Kyoto University | RIKEN HARIMA Institute |
| Published papers (PubMed IDs) | Under investigation |
| Patent (Japan, overseas) | Under investigation |
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