More information XML output

Name HEAT
Aliases H-InvDB Enrichment Analysis Tool
Description

H-InvDB Enrichment Analysis Tool (HEAT) is a data-mining tool for automatically identifying features specific to a given human gene set. HEAT searches for H-InvDB annotations that are significantly enriched in a user-defined gene set, as compared with the entire H-InvDB representative transcripts. This technique is called Gene Set Enrichment Analysis (GSEA), and is popularly used in analyzing results of microarray experiments. Fisher's exact probability is used in statistical tests of HEAT.

Type Tool
Main Institutes of management Biomedicinal Information Research Center (BIRC), National Institute of Advanced Industrial Science and Technology (AIST)
Country of the Institute Japan
URL of the site http://hinv.jp/HEAT/search.php?lang=en
Interface GUI
Input example

Submit two or more human gene IDs into the "Gene-Set Submission" text-box, and push the "Submit" button. Then, after confirming converted IDs, push the "Execute" button to show the enriched features of the gene list.

Keyword
GSEA | human gene | annotation
Amount of the all data for download(Mbyte) | Method to obtain the all data. 0 | None
External resources (databases) in building the product. ID Converter System | H-InvDB
Data type Annotation
Biological species in the main concern Human
Conditions of use Attribution&Share Alike
Frequency of updates (in last two years) 2
Last date of updates (date of confirmation) 2011/07/27 (2011/07/29)
Main IDs used in the products HIT | HIX | accession number | HUGO gene symbol
How to make a link to get access to each IDs. None
external databases to which this database/tool have links

InterPro, SCOP, KEGG pathway, G-integra, HIF

Published papers (PubMed IDs)

Imanishi T, Itoh T, Suzuki Y, O'Donovan C, Fukuchi S, Koyanagi KO, Barrero RA, Tamura T, Yamaguchi-Kabata Y, Tanino M, Yura K, Miyazaki S, Ikeo K, Homma K, Kasprzyk A, Nishikawa T, Hirakawa M, Thierry-Mieg J, Thierry-Mieg D, Ashurst J, Jia L, Nakao M, Thomas MA, Mulder N, Karavidopoulou Y, Jin L, Kim S, Yasuda T, Lenhard B, Eveno E, Suzuki Y, Yamasaki C, Takeda J, Gough C, Hilton P, Fujii Y, Sakai H, Tanaka S, Amid C, Bellgard M, Bonaldo Mde F, Bono H, Bromberg SK, Brookes AJ, Bruford E, Carninci P, Chelala C, Couillault C, de Souza SJ, Debily MA, Devignes MD, Dubchak I, Endo T, Estreicher A, Eyras E, Fukami-Kobayashi K, Gopinath GR, Graudens E, Hahn Y, Han M, Han ZG, Hanada K, Hanaoka H, Harada E, Hashimoto K, Hinz U, Hirai M, Hishiki T, Hopkinson I, Imbeaud S, Inoko H, Kanapin A, Kaneko Y, Kasukawa T, Kelso J, Kersey P, Kikuno R, Kimura K, Korn B, Kuryshev V, Makalowska I, Makino T, Mano S, Mariage-Samson R, Mashima J, Matsuda H, Mewes HW, Minoshima S, Nagai K, Nagasaki H, Nagata N, Nigam R, Ogasawara O, Ohara O, Ohtsubo M, Okada N, Okido T, Oota S, Ota M, Ota T, Otsuki T, Piatier-Tonneau D, Poustka A, Ren SX, Saitou N, Sakai K, Sakamoto S, Sakate R, Schupp I, Servant F, Sherry S, Shiba R, Shimizu N, Shimoyama M, Simpson AJ, Soares B, Steward C, Suwa M, Suzuki M, Takahashi A, Tamiya G, Tanaka H, Taylor T, Terwilliger JD, Unneberg P, Veeramachaneni V, Watanabe S, Wilming L, Yasuda N, Yoo HS, Stodolsky M, Makalowski W, Go M, Nakai K, Takagi T, Kanehisa M, Sakaki Y, Quackenbush J, Okazaki Y, Hayashizaki Y, Hide W, Chakraborty R, Nishikawa K, Sugawara H, Tateno Y, Chen Z, Oishi M, Tonellato P, Apweiler R, Okubo K, Wagner L, Wiemann S, Strausberg RL, Isogai T, Auffray C, Nomura N, Gojobori T, and Sugano S (2004) Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones. PLoS Biology 2: 856-875. | Genome Information Integration Project and H-Invitational 2 (2008) The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. Nucleic Acids Research 36 (Database Issue): D793-D799.

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Project name Genome Information Integration Project (GIIP)
Area Genome Informatics
Purpose # construction of "all human gene catalogue" # development of annotation technique based on H-InvDB # data integration of disease, gene expression and PPI information
Introduction GIIP project was a model project of METI, which executed for 3 years since 2005 to 2007. The representative institute of the commission was Japan Biological Informatics Consortium (JBIC) and also the other six research institutes took their parts. The aim of the project is to construct an annotated human gene database of the world highest quality, based on H-Invitational Database (H-InvDB).
Keyword genome | gene | annotation | integrated | database
Patent (Japan, overseas) JP2006323830(A) | JP2008097189(A)
Archives
The report on "Genome Information Integration Project (GIIP)" 2005-2007. Japanese.
Product (Database, Tool) Nothing